Lyme Disease: Tick-borne Illness and Co-infections

 

Learn More about our Tickborne Illness and Co-infections Test

Dried Blood Spot (at home)

This test measures antibodies against bacteria and viruses that may have been active in the past (IgG) and recent or reactivated infections (IgM). It is one of the most specific and sensitive tests available for Lyme Disease according to published data by Vibrant Wellness, read here, and internal quality data read here.

This test measures: (Basic panel includes only)

  • Borellia species - a number of Borellia species identified to cause Lyme disease
  • Babesia, Bartonella – common bacterial infections from ticks
  • Ehrlichia and Anaplasma

Also included on the advanced panel are the following:

  • Mycoplasma pneumoniae, Rickettsia, Streptococcal A bacteria
  • Viral-co-infections such as Cocksackie, tickborne encephalitis virus, Toxoplasma gondii

Plus viral infections:

  • EBV / Epstein Barr Virus - both IgG and IgM of the Early Antigen, EBNA and VCA antigens which can help to discriminate between older/ previous infections which are very common, or recent or reactivated infection which can be contributing to chronic illness
  • Cytomegalovirus, Parvovirus 19 – commonly found in the population as previous infections
  • Herpes Simplex Virus – HSV-1 and HSV-2
  • Human herpesvirus – HHV-6 and HHV-7

Ciara had Long Covid from an infection 3 years prior. Many of her symptoms had improved with treatment and various interventions but she still suffered from excessive fatigue, PEM, headache and sore throat. She was unable to work full time and while her function had improved from her worst point, she was unable to exercise and she still had to pace carefully. She did not recall a previous tick bite, but had spent a very significant amount of time in the countryside and woods where deer were common. In order to investigate whether she had a reactivation of Lyme Disease, she carried out a tickborne illness and co-infections panel.

Key findings (excerpt from test):

  • Positive for Borrelia burgdorferi IgG – reached the positive threshold for previous infection
  • Elevated IgM against Bartonella – a positive finding for recent or reactivated infection
  • With subsequent treatment from her consultant along with supportive herbs, an anti-microbial and immune supportive protocol, Ciara improved significantly. Her throat symptoms cleared, fatigue improved significantly and she no longer experienced PEM. Ciara made a full recovery after her treatment.

Lyme disease FAQ

How can this test help me feel better?
Lyme disease and tick-borne infections can contribute to a wide range of symptoms, including fatigue, joint pain, brain fog, headaches, and recurrent infections. This test looks for Borrelia species along with other common co-infections like Babesia, Bartonella, Ehrlichia, and Anaplasma. By identifying past or active exposures, we can guide personalised treatment and lifestyle strategies to support immune function, reduce inflammation, and improve energy and overall wellbeing. The advanced panel can also detect related bacterial and viral co-infections that may complicate recovery.
I have Long Covid/ME/CFS – can this test help me?
Post-viral or post-infectious syndromes often involve immune dysregulation and lingering inflammation. In some cases, co-occurring or reactivated tick-borne infections may contribute to persistent fatigue, cognitive issues, or musculoskeletal symptoms. This test does not diagnose ME/CFS or Long Covid, but it can help identify potential hidden or chronic infections that may be impacting your recovery. Understanding your infection profile allows for a more targeted and evidence-informed support strategy.
Can I combine this test with other panels?
Yes. Lyme and tick-borne testing is often most informative when interpreted alongside: • Viral panels to assess co-infections • Immune or inflammatory markers • Functional nutritional profiles for supporting recovery Combining panels can provide a more holistic view of immune function, infection burden, and metabolic resilience, helping us tailor a precise, personalised plan.
I don’t think I have ever been bitten by a tick, can this test still help?
Yes. Tick bites are often unnoticed, and some infections can be transmitted via very small or early-stage ticks. Symptoms may develop weeks to months after exposure, and infections can remain latent or subclinical. Testing can help uncover hidden infections that may be contributing to unexplained fatigue, joint pain, cognitive symptoms, or other systemic issues — even if you don’t recall a bite.
How accurate is this test?
Our research director Ciara Wright PhD looked extensively into the available tick tests on the market. This test from Vibrant Wellness has published data on blinded samples from the Centre of Disease Control in the USA, and they have published their internal quality control findings also. This transparency, and the excellent sensitivity and specificity reported by this lab has led us to recommending this test over any other. Please see relevant publications here: Vibrant-Wellness Validation Study | Vibrant-Wellness-Tickborne-Panel-Internal Quality Data