Immune related infertility
The immune system plays a critical role in the protective environment for embryo implantation and foetal development.
Many couples who previously had no clear reason for their fertility issues or recurrent miscarriage have subsequently found that an immune imbalance might be a piece of the puzzle. This new field of research has given hope to many couples who might otherwise be considered as having ‘unexplained infertility’.
Key Facts
- The immune system should adapt to tolerate an implanting embryo and growing foetus but in some cases, an immune imbalance or excess inflammation prevents development
- The aggressive activity of NK cells are linked to increased risk of infertility, reduced rates of conception and increased risk for miscarriage
- Advanced testing can also identify other cells of the immune system that are out of balance such as Th1/ Th2 balance, cells linked with autoimmune disease and inflammatory cytokines
- Identifying the source of inflammation such as in the gut microbiome or the vaginal microbiome and treating underlying bacterial imbalances or infection is very helpful
- An anti-inflammatory diet, supplement protocol and medicinal mushrooms can be very effective at restoring immune balance for a healthy pregnancy.
- Supplement protocols are adapted to complement IVF treatment and medications as necessary
Best Test Options
Advanced Immune Test
Autoimmune Screening
Vaginal Microbiome – Vaginal Ecologix
Gut Microbiome – GI Ecologix
Patient Story
History
Martha attended our clinic after 2 failed embryo transfers using donor eggs. Prior to this she had a history of ‘unexplained infertility’ and had opted to try with donor eggs but this was still unsuccessful.
Tests
To assess the environment for implantation, Martha carried out advanced immune testing and vaginal microbiome analysis.
High levels of inflammatory cytokines were detected on the advanced immune test.
Bacteria associated with Bacterial Vaginosis (BV) were detected on the vaginal microbiome test along with low levels of beneficial bacteria.
Plan
A supplement protocol was designed to improve the environment of the vaginal microbiome including prebiotics, probiotics and anti-inflammatory supplements. Martha received treatment from her GP for BV and she followed a maintenance plan from our clinic as BV has a high rate of reoccurrence.
Repeat test
A repeat microbiome test showed that Martha’s BV bacteria had reduced significantly. A protocol was designed to maintain vaginal health into pregnancy.
Outcome
Martha discussed her immune tests with her clinic and they amended her medication protocol. The next embryo transfer cycle was successful and Martha went on to have a successful pregnancy and a healthy baby girl.
“Our little miracle is here finally! It was a long road but finally she is here and we are absolutely thrilled!”
