Male Microbiome - Semen Microbiome Test

 

Learn More about our Male Microbiome Test

Semen sample (at home)

This very comprehensive and ground-breaking test assesses the seminal microbiome (bacteria and yeast) – a key ecosystem for reproductive health. Using quantitative real-time PCR (qPCR), this is the most technologically advanced microbiome profile to provide accurate analysis of microbiota abundance and identification. Until recently, some fertility clinics or specialists would give antibiotics as a precaution, not knowing whether they were needed or whether the right antibiotic was being used. With this very comprehensive test, it can now be accurately determined which unwanted bacteria might be present and the appropriate treatment used.

  • Normal bacterial levels of Lactobacillus and other commensal bacteria commonly found at low levels
  • Opportunistic bacteria which can cause imbalances if they overgrow
  • Bacteria associated with Bacterial Vaginosis (BV) in women which can be passed between partners
  • Bacteria which can be passed between partners, causing immune responses and fertility issues in both partners, but possibly no symptoms
  • Bacteria that cause sexually transmitted infections (STI) like chlamydia and gonorrhoea
  • Yeast infections or Candida
  • Viruses including HSV, CMV and HHV-6

Donal was trying to conceive with his partner through IVF/ ICSI. He had elevated DNA fragmentation and low sperm count. He was also seen by a urologist and diagnosed with a small varicocele. He had no symptoms of infection, nor had his partner.

He carried out this microbiome test to check for any underlying bacterial imbalances to see if he could reduce oxidative stress and damage to the sperm. Though he had no symptoms at all, the test results showed a significant imbalance with high numbers of several unwanted bacteria.

His urologist prescribed antibiotics based on the test results. He also maintained a mild antimicrobial supplement and a probiotic until their next IVF cycle. His partner was tested for similar bacteria and also took the antimicrobial supplement and probiotics. They conceived at their next cycle and had a beautiful baby boy.

Key findings (excerpt from test):

  • High levels of BV-associated bacteria which are most commonly tested in women but can be passed between partners
  • Very high levels of additional bacteria which could cause an immune reaction and oxidative stress in the testes. These bacteria can also be passed between partners
  • No candida, yeast, viruses or sexually transmitted infections (STI) were detected

Male Microbiome FAQ

How can this test help with male fertility?
The Male Microbiome Test assesses the bacterial and fungal balance in the male reproductive tract, which can influence sperm quality, motility, and overall reproductive health. Imbalances, even if mild, may contribute to oxidative stress, inflammation, and suboptimal fertility outcomes. This test provides actionable data so we can recommend personalised interventions — from targeted probiotics and diet adjustments to lifestyle strategies — that support a healthier microbiome and potentially improve fertility outcomes.
My DNA fragmentation is high, can this test help?
Yes. High sperm DNA fragmentation can be influenced by oxidative stress, inflammation, and microbial imbalances in the male reproductive tract. The Male Microbiome Test can help identify bacterial or fungal patterns that may be contributing to DNA damage, even if standard infection tests are normal and there are no symptoms. With this insight, we can create a personalised strategy — including targeted microbiome support, antioxidants, and lifestyle optimisation — aimed at reducing DNA fragmentation and supporting better fertility outcomes.
I have absolutely no symptoms, can this test still help?
Yes. Male reproductive tract imbalances are often silent — meaning you may feel healthy but still have microbiome patterns that could affect fertility. Early detection allows for preventive action, optimising sperm health and reducing potential risks for conception.
I have already had a swab and urinalysis with my GP, how is this different?
Routine swabs and urinalysis detect overt infections or obvious inflammation, but they do not measure the full microbial ecosystem of the male reproductive tract or its influence on fertility. This test goes deeper, identifying subclinical imbalances, bacterial overgrowth, or fungi that can affect sperm function and quality.
My partner had some unhelpful bacteria on her microbiome test, does that mean I should do this test?
Ideally, yes. Male and female reproductive microbiomes interact closely. In some cases, imbalances in one partner can influence the other, potentially affecting fertility or increasing the risk of recurrent infections. Testing the male microbiome helps ensure both partners’ reproductive health is optimised, enabling tailored interventions to support healthy conception.